In some patients symptoms may not appear for the first six months after birth. Some other common symptoms that are experienced by X-SCID patients include failure to thrive, gut problems, skin problems, and muscle hypotonia. Other common infections experienced by individuals with X-SCID include diarrhea, sepsis, and otitis media. Recurrent eczema-like rashes are also a common symptom. Candidiasis involves moist areas of the body such as skin, the mouth, respiratory tract, and vagina symptoms of oral candidiasis include difficulty in swallowing, pain on swallowing and oral lesions. A telltale sign of X-SCID is candidiasis, a type of fungal infection caused by Candida albicans. This is followed by viral infections such as pneumonitis, an inflammation of the lung which produces common symptoms such as cough, fever, chills, and shortness of breath. This occurs due to the decreased amount of immunoglobulin G (IgG) levels in the infant during the three-month stage. People with X-SCID often have infections very early in life, before three months of age. This gene encodes the interleukin receptor common gamma chain protein, which is a cytokine receptor sub-unit that is part of the receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. It is an X-linked recessive inheritance trait, stemming from a mutated (abnormal) version of the IL2RG gene located on the X-chromosome. In the absence of T cell help, B cells become defective. X-linked severe combined immunodeficiency ( X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells. X-linked recessive is the inheritance pattern of this disorder Medical condition X-linked severe combined immunodeficiency
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