![]() Mortality was recorded in 210 children (75.8%).Ĭonclusion: We document an exponential rise in number of cases diagnosed to have SCID over the last 10 years, probably as a result of increasing awareness and improvement in diagnostic facilities at various centers in India. Only 23 children (8.3%) received hematopoietic stem cell transplantation (HSCT). Median (inter-quartile range) age of onset of clinical symptoms and diagnosis was 2.5 months (1, 5) and 5 months (3.5, 8), respectively. Results: We obtained data on 277 children 254 were categorized as SCID and 23 as CID. Diagnosis of SCID/combined immune deficiency (CID) was based on 2018 European Society for Immunodeficiencies working definition for SCID. Twelve (12) centers provided necessary details which were then compiled and analyzed. We collated clinical, laboratory, and molecular details of patients with clinical profile suggestive of SCID and their outcomes. Methods: A detailed case proforma in an Excel format was prepared by one of the authors (PV) and was sent to centers in India that care for patients with primary immunodeficiency diseases. Objective: To describe clinical and laboratory features of SCID diagnosed at immunology centers across India. Data on SCID from developing countries are scarce.
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